InnateDB Protein
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IDBP-154585.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Atg14
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Protein Name
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VATG14 autophagy related 14 homolog (S. cerevisiae)
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Synonyms
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000039047
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InnateDB Gene
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IDBG-154583 (Atg14)
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Protein Structure
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Function |
Required for both basal and inducible autophagy. Plays a role in autophagosome formation and MAP1LC3/LC3 conjugation to phosphatidylethanolamine. Promotes BECN1 translocation from the trans-Golgi network to autophagosomes (By similarity). Enhances PIK3C3 activity in a BECN1-dependent manner. Modulates the hepatic lipid metabolism. {ECO:0000250, ECO:0000269PubMed:19270693, ECO:0000269PubMed:19270696, ECO:0000269PubMed:22992773}.
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Subcellular Localization |
Cytoplasm. Endoplasmic reticulum membrane; Peripheral membrane protein. Preautophagosomal structure membrane; Peripheral membrane protein. Note=Cytosolic under nutrient-rich conditions. Following autophagy stimuli, such as starvation or rapamycin induction, predominantly detected in cytoplasmic foci, identified as isolation membranes and autophagosomes. Accumulates on highly curved PtdIns(3)P enriched autophagic membrane via its BATS domain to sense and maintain membrane curvature. Localizes also to discrete punctae along the ciliary axoneme and to the base of the ciliary axoneme.
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Disease Associations |
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Tissue Specificity |
Widely expressed. {ECO:0000269PubMed:18843052}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
Experimentally validated |
Total |
5
[view]
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Protein-Protein |
5
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
11 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1261775
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InterPro |
IPR018791
UV radiation resistance protein/autophagy-related protein 14
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PFAM |
PF10186
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q8CDJ3
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PhosphoSite |
PhosphoSite-Q8CDJ3
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
100504663
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UniGene |
Mm.470462
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RefSeq |
NP_766187
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MGI ID |
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MGI Symbol |
Atg14
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OMIM |
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CCDS |
CCDS26989
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HPRD |
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IMGT |
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EMBL |
AK029967
AK054196
AK173037
BC025038
BC057360
BC090995
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GenPept |
AAH25038
AAH57360
AAH90995
BAC26705
BAC35689
BAD32315
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