Version 5.4
Mus musculus Protein: Odf2
Summary
InnateDB Protein IDBP-154647.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Odf2
Protein Name outer dense fiber of sperm tails 2
Synonyms AI848335; MMTEST29;
Species Mus musculus
Ensembl Protein ENSMUSP00000049272
InnateDB Gene IDBG-154645 (Odf2)
Protein Structure
UniProt Annotation
Function Seems to be a major component of sperm tail outer dense fibers (ODF). ODFs are filamentous structures located on the outside of the axoneme in the midpiece and principal piece of the mammalian sperm tail and may help to maintain the passive elastic structures and elastic recoil of the sperm tail. May have a modulating influence on sperm motility. Functions as a general scaffold protein that is specifically localized at the distal/subdistal appendages of mother centrioles. Component of the centrosome matrix required for the localization of PLK1 and NIN to the centrosomes. Required for the formation and/or maintenance of normal CETN1 assembly (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269PubMed:15852003}. Cell projection, cilium {ECO:0000269PubMed:15852003}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269PubMed:15852003}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269PubMed:15852003}. Note=Localized at the microtubule organizing centers in interphase and spindle poles in mitosis. Localized at the distal/subdistal appendages of mother centrioles.
Disease Associations
Tissue Specificity Testis-specific (at protein level). Expressed in spermatids at tubular stage V of the spermatogenic cycle. Highly expressed in the cytoplasm of elongating spermatids (tubular stages X/XI). In step 14/15 spermatids of tubular stage III/IV low expression detected. No expression detected in other testicular cells as well as the early round of spermatids. {ECO:0000269PubMed:9045620, ECO:0000269PubMed:9740324}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005200 structural constituent of cytoskeleton
Biological Process
GO:0007275 multicellular organismal development
GO:0007286 spermatid development
Cellular Component
GO:0000922 spindle pole
GO:0001520 outer dense fiber
GO:0005814 centriole
GO:0005874 microtubule
GO:0005929 cilium
Protein Structure and Domains
PDB ID MGI:1098824
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt A3KGV1
PhosphoSite PhosphoSite-A3KGV1
TrEMBL Q8CH89
UniProt Splice Variant
Entrez Gene 18286
UniGene Mm.474899
RefSeq
MGI ID
MGI Symbol Odf2
OMIM
CCDS CCDS50556
HPRD
IMGT
EMBL AB097861 AF000968 AF034105 AK143726 AK148523 AK168415 AL928926 BC057001
GenPept AAB65157 AAB87525 AAH57001 BAC44900 BAE25517 BAE28599 BAE40330 CAM46225 CAM46226 CAM46229 CAM46230 CAM46231 CAM46232

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca