InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Lman1

Summary

InnateDB Protein

IDBP-154879.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Lman1

Protein Name

lectin, mannose-binding, 1

Synonyms

2610020P13Rik; AI326273; AU043785; C730041J05; ERGIC53; F5F8D; gp58; MCFD1; MR60; P58;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000040140

InnateDB Gene

IDBG-154877 (Lman1)

Protein Structure

UniProt Annotation

Function

Mannose-specific lectin. May recognize sugar residues of glycoproteins, glycolipids, or glycosylphosphatidyl inositol anchors and may be involved in the sorting or recycling of proteins, lipids, or both. The LMAN1-MCFD2 complex forms a specific cargo receptor for the ER-to-Golgi transport of selected proteins (By similarity). {ECO:0000250}.

Subcellular Localization

Endoplasmic reticulum-Golgi intermediate compartment membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 30 interaction(s) predicted by orthology.

Experimentally validated
Total	13 [view]
Protein-Protein	13 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	30 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0046872	metal ion binding

Biological Process

GO:0006888	ER to Golgi vesicle-mediated transport
GO:0007029	endoplasmic reticulum organization
GO:0007030	Golgi organization
GO:0010638	positive regulation of organelle organization
GO:0015031	protein transport

Cellular Component

GO:0000139	Golgi membrane
GO:0005789	endoplasmic reticulum membrane
GO:0005793	endoplasmic reticulum-Golgi intermediate compartment
GO:0005794	Golgi apparatus
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030017	sarcomere
GO:0030134	ER to Golgi transport vesicle
GO:0033116	endoplasmic reticulum-Golgi intermediate compartment membrane
GO:0070062	extracellular vesicular exosome