InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Prelid1

Summary

InnateDB Protein

IDBP-155284.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Prelid1

Protein Name

PRELI domain containing 1

Synonyms

2610524G07Rik; Preli;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000021942

InnateDB Gene

IDBG-155282 (Prelid1)

Protein Structure

UniProt Annotation

Function

Involved in the modulation of the mitochondrial apoptotic pathway by ensuring the accumulation of cardiolipin (CL) in mitochondrial membranes. In vitro, the TRIAP1:PRELID1 complex mediates the transfer of phosphatidic acid (PA) between liposomes and probably functions as a PA transporter across the mitochondrion intermembrane space to provide PA for CL synthesis in the inner membrane. Regulates the mitochondrial apoptotic pathway in primary Th cells. Regulates Th cell differentiation by down-regulating STAT6 thereby reducing IL-4-induced Th2 cell number. May be important for the development of vital and immunocompetent organs (By similarity). {ECO:0000250}.

Subcellular Localization

Mitochondrion {ECO:0000269PubMed:14640972}. Mitochondrion intermembrane space {ECO:0000250}.

Disease Associations

Tissue Specificity

Abundantly expressed in all tissues tested except testis with highest levels in thymus. {ECO:0000269PubMed:14640972}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:1990050	phosphatidic acid transporter activity

Biological Process

GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0010917	negative regulation of mitochondrial membrane potential
GO:0010950	positive regulation of endopeptidase activity
GO:0015914	phospholipid transport
GO:0043066	negative regulation of apoptotic process
GO:0045580	regulation of T cell differentiation
GO:0051881	regulation of mitochondrial membrane potential
GO:0070234	positive regulation of T cell apoptotic process
GO:0090201	negative regulation of release of cytochrome c from mitochondria
GO:0097035	regulation of membrane lipid distribution
GO:1901857	positive regulation of cellular respiration
GO:1902511	negative regulation of apoptotic DNA fragmentation
GO:2001140	positive regulation of phospholipid transport