InnateDB Protein
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IDBP-155875.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Gdi1
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Protein Name
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guanosine diphosphate (GDP) dissociation inhibitor 1
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Synonyms
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GDIA; GDIalpha;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000015435
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InnateDB Gene
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IDBG-155873 (Gdi1)
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Protein Structure
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Function |
Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Promotes the dissociation of GDP-bound Rab proteins from the membrane and inhibits their activation. Promotes the dissociation of RAB1A, RAB3A, RAB5A and RAB10 from membranes.
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Subcellular Localization |
Cytoplasm {ECO:0000250}. Golgi apparatus, trans-Golgi network {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
High expression in brain, lower in other tissues.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 23 interaction(s) predicted by orthology.
Experimentally validated |
Total |
4
[view]
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Protein-Protein |
4
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
23 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:99846
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InterPro |
IPR000806
Rab GDI protein
IPR018203
GDP dissociation inhibitor
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PFAM |
PF00996
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PRINTS |
PR00892
PR00891
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
P50396
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PhosphoSite |
PhosphoSite-P50396
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TrEMBL |
D6RI86
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UniProt Splice Variant |
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Entrez Gene |
14567
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UniGene |
Mm.392083
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RefSeq |
NP_034403
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MGI ID |
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MGI Symbol |
Gdi1
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OMIM |
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CCDS |
CCDS30227
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HPRD |
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IMGT |
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EMBL |
AF251042
AF441240
AK028880
AK156224
AK171216
AL807376
BC010220
BC013758
BC037598
U07950
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GenPept |
AAB16907
AAH10220
AAH13758
AAH37598
AAK49815
AAL60197
BAC26169
BAE33632
BAE42320
CAM24345
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