Version 5.4
Mus musculus Protein: Parp2
Summary
InnateDB Protein IDBP-156337.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Parp2
Protein Name poly (ADP-ribose) polymerase family, member 2
Synonyms Adprt2; Adprtl2; ARTD2; Aspartl2; C78626; PARP-2;
Species Mus musculus
Ensembl Protein ENSMUSP00000048877
InnateDB Gene IDBG-156335 (Parp2)
Protein Structure
UniProt Annotation
Function Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks.
Subcellular Localization Nucleus.
Disease Associations
Tissue Specificity Widely expressed; the highest levels were in testis followed by ovary. Expression is correlated with proliferation, with higher levels occurring during early fetal development and organogenesis and in the highly proliferative cell compartments of adult.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003950 NAD+ ADP-ribosyltransferase activity
GO:0005515 protein binding
Biological Process
GO:0006281 DNA repair
GO:0006284 base-excision repair
GO:0006471 protein ADP-ribosylation
GO:0097191 extrinsic apoptotic signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
Protein Structure and Domains
PDB ID MGI:1341112
InterPro IPR004102 Poly(ADP-ribose) polymerase, regulatory domain
IPR008893 WGR domain
IPR012317 Poly(ADP-ribose) polymerase, catalytic domain
PFAM PF02877
PF05406
PF00644
PRINTS
PIRSF
SMART SM00773
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O88554
PhosphoSite PhosphoSite-O88554
TrEMBL
UniProt Splice Variant
Entrez Gene 11546
UniGene
RefSeq NP_033762
MGI ID 1GS0
MGI Symbol Parp2
OMIM
CCDS CCDS27025
HPRD
IMGT
EMBL AF072521 AF191547 AJ007780 BC062150
GenPept AAC25415 AAH62150 AAK13253 CAA07679

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca