InnateDB Protein
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IDBP-156443.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Aadat
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Protein Name
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aminoadipate aminotransferase
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Synonyms
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Aadt; AI875679; Kat2; KATII; mKat-2;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000078436
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InnateDB Gene
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IDBG-156441 (Aadat)
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Protein Structure
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Function |
Transaminase with broad substrate specificity. Has transaminase activity towards aminoadipate, kynurenine, methionine and glutamate. Shows activity also towards tryptophan, aspartate and hydroxykynurenine. Accepts a variety of oxo-acids as amino- group acceptors, with a preference for 2-oxoglutarate, 2- oxocaproic acid, phenylpyruvate and alpha-oxo-gamma-methiol butyric acid. Can also use glyoxylate as amino-group acceptor (in vitro) (By similarity). {ECO:0000250}.
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Subcellular Localization |
Mitochondrion {ECO:0000305}.
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Disease Associations |
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Tissue Specificity |
Expressed mainly in kidney and to a lesser amount in liver and brain. {ECO:0000269PubMed:10441733}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
1
[view]
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Protein-Protein |
1
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
Accession |
GO Term |
GO:0016212
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kynurenine-oxoglutarate transaminase activity
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GO:0030170
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pyridoxal phosphate binding
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GO:0042803
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protein homodimerization activity
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GO:0047536
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2-aminoadipate transaminase activity
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1345167
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InterPro |
IPR004839
Aminotransferase, class I/classII
IPR015424
Pyridoxal phosphate-dependent transferase
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PFAM |
PF00155
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9WVM8
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PhosphoSite |
PhosphoSite-Q9WVM8
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
23923
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UniGene |
Mm.35020
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RefSeq |
NP_035964
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MGI ID |
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MGI Symbol |
Aadat
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OMIM |
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CCDS |
CCDS22320
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HPRD |
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IMGT |
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EMBL |
AF072376
AK075578
BC012637
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GenPept |
AAD39680
AAH12637
BAC35833
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