InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Hmbs

Summary

InnateDB Protein

IDBP-156817.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hmbs

Protein Name

hydroxymethylbilane synthase

Synonyms

PBGD; T25658; Ups; Uros1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000076575

InnateDB Gene

IDBG-156815 (Hmbs)

Protein Structure

UniProt Annotation

Function

Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004418	hydroxymethylbilane synthase activity

Biological Process

GO:0006782	protoporphyrinogen IX biosynthetic process
GO:0018160	peptidyl-pyrromethane cofactor linkage
GO:0033014	tetrapyrrole biosynthetic process

Cellular Component

Protein Structure and Domains

PDB ID

MGI:96112

InterPro

IPR000860 Tetrapyrrole biosynthesis, hydroxymethylbilane synthase
IPR022417 Porphobilinogen deaminase, N-terminal
IPR022418 Porphobilinogen deaminase, C-terminal

PFAM

PF01379
PF03900

PRINTS

PR00151

PIRSF

PIRSF001438

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt