Version 5.4
Mus musculus Protein: Afap1
Summary
InnateDB Protein IDBP-157730.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Afap1
Protein Name actin filament associated protein 1
Synonyms 2600003E23Rik; 9630044L16Rik; Afap; AI848729; mKIAA3018;
Species Mus musculus
Ensembl Protein ENSMUSP00000067779
InnateDB Gene IDBG-157728 (Afap1)
Protein Structure
UniProt Annotation
Function Can cross-link actin filaments into both network and bundle structures. May modulate changes in actin filament integrity and induce lamellipodia formation. May function as an adapter molecule that links other proteins, such as SRC and PKC to the actin cytoskeleton (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm, cytoskeleton {ECO:0000250}. Note=Localizes with stress fibers in quiescent cells, concentrated in cell motility structures such as lamellipodia, filopodia and membrane ruffles. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0017124 SH3 domain binding
Biological Process
Cellular Component
GO:0005737 cytoplasm
GO:0005925 focal adhesion
GO:0015629 actin cytoskeleton
Protein Structure and Domains
PDB ID MGI:1917542
InterPro IPR001849 Pleckstrin homology domain
PFAM PF00169
PRINTS
PIRSF
SMART SM00233
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q80YS6
PhosphoSite PhosphoSite-Q80YS6
TrEMBL Q9CT56
UniProt Splice Variant
Entrez Gene 70292
UniGene Mm.473806
RefSeq NP_081649
MGI ID
MGI Symbol Afap1
OMIM
CCDS CCDS19236
HPRD
IMGT
EMBL AC127275 AC141898 AK011153 AK129483 AK147706 AK148000 AK161385 BC050814
GenPept AAH50814 BAB27434 BAC98293 BAE28086 BAE28280 BAE36364

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca