InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Gldc

Summary

InnateDB Protein

IDBP-157791.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gldc

Protein Name

glycine decarboxylase

Synonyms

D030049L12Rik; D19Wsu57e;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000025778

InnateDB Gene

IDBG-157787 (Gldc)

Protein Structure

UniProt Annotation

Function

The glycine cleavage system catalyzes the degradation of glycine. The P protein (GLDC) binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein (GCSH) (By similarity). {ECO:0000250}.

Subcellular Localization

Mitochondrion {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004375	glycine dehydrogenase (decarboxylating) activity
GO:0016829	lyase activity
GO:0030170	pyridoxal phosphate binding

Biological Process

GO:0006520	cellular amino acid metabolic process
GO:0006544	glycine metabolic process
GO:0006546	glycine catabolic process
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005739

mitochondrion

Protein Structure and Domains

PDB ID

MGI:1341155

InterPro

IPR001597 Aromatic amino acid beta-eliminating lyase/threonine aldolase
IPR003437 Glycine cleavage system P protein, homodimeric
IPR015424 Pyridoxal phosphate-dependent transferase
IPR020580 Glycine cleavage system P-protein, N-terminal

PFAM

PF01212
PF02347

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q91W43

PhosphoSite