Version 5.4
Homo sapiens Protein: RRN3
Summary
InnateDB Protein IDBP-15874.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RRN3
Protein Name RRN3 RNA polymerase I transcription factor homolog (S. cerevisiae)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000198767
InnateDB Gene IDBG-15872 (RRN3)
Protein Structure
UniProt Annotation
Function Required for efficient transcription initiation by RNA polymerase I. Required for the formation of the competent preinitiation complex (PIC). Dissociates from pol I as a consequence of transcription. In vitro, cannot activate transcription in a subsequent transcription reaction (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus, nucleolus {ECO:0000269PubMed:11250903}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 29 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 29 [view]
Protein-Protein 29 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003743 translation initiation factor activity
GO:0005488 binding
GO:0070063 RNA polymerase binding
Biological Process
GO:0001701 in utero embryonic development
GO:0006352 DNA-templated transcription, initiation
GO:0006360 transcription from RNA polymerase I promoter
GO:0006361 transcription initiation from RNA polymerase I promoter
GO:0006413 translational initiation
GO:0007000 nucleolus organization
GO:0007028 cytoplasm organization
GO:0008283 cell proliferation
GO:0010467 gene expression
GO:0042254 ribosome biogenesis
GO:0045893 positive regulation of transcription, DNA-templated
GO:0048872 homeostasis of number of cells
GO:1902254 negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator
GO:2000142 regulation of DNA-dependent transcription, initiation
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
Protein Structure and Domains
PDB ID
InterPro IPR007991 RNA polymerase I specific transcription initiation factor RRN3
IPR016024 Armadillo-type fold
PFAM PF05327
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9NYV6
PhosphoSite PhosphoSite-Q9NYV6
TrEMBL B4E3T2
UniProt Splice Variant
Entrez Gene 54700
UniGene Hs.460078
RefSeq NP_060897
HUGO HGNC:30346
OMIM 605121
CCDS CCDS10559
HPRD 12004
IMGT
EMBL AC139256 AF227156 AJ272050 AK302994 AK304856 AK314769 BC071868 BC132688 BC132690 CH471301
GenPept AAF66160 AAH71868 AAI32689 AAI32691 BAG37307 BAG64131 BAG65594 CAC07955 EAW54754

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca