InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TIAM1

Summary

InnateDB Protein

IDBP-1599.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TIAM1

Protein Name

T-cell lymphoma invasion and metastasis 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000286827

InnateDB Gene

IDBG-1597 (TIAM1)

Protein Structure

UniProt Annotation

Function

Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP- dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Activates RAC1, CDC42, and to a lesser extent RHOA. Required for normal cell adhesion and cell migration. {ECO:0000269PubMed:20361982}.

Subcellular Localization

Cell junction. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Detected at the boundary between cells with actin-rich protrusions (By similarity). Presence of KRIT1, CDH5 and RAP1B is required for its localization to the cell junction. {ECO:0000250}.

Disease Associations

Tissue Specificity

Found in virtually all analyzed tumor cell lines including B- and T-lymphomas, neuroblastomas, melanomas and carcinomas.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 41 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	41 [view]
Protein-Protein	40 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005057	receptor signaling protein activity
GO:0005085	guanyl-nucleotide exchange factor activity
GO:0005089	Rho guanyl-nucleotide exchange factor activity
GO:0005515	protein binding
GO:0005543	phospholipid binding
GO:0030676	Rac guanyl-nucleotide exchange factor activity
GO:0046875	ephrin receptor binding

Biological Process

GO:0007160	cell-matrix adhesion
GO:0007165	signal transduction
GO:0007264	small GTPase mediated signal transduction
GO:0016477	cell migration
GO:0016601	Rac protein signal transduction
GO:0032321	positive regulation of Rho GTPase activity
GO:0032855	positive regulation of Rac GTPase activity
GO:0035023	regulation of Rho protein signal transduction
GO:0043065	positive regulation of apoptotic process
GO:0043087	regulation of GTPase activity
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0048013	ephrin receptor signaling pathway
GO:0050772	positive regulation of axonogenesis
GO:0051056	regulation of small GTPase mediated signal transduction
GO:0097190	apoptotic signaling pathway

Cellular Component

GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0005911	cell-cell junction
GO:0031234	extrinsic component of cytoplasmic side of plasma membrane
GO:0044291	cell-cell contact zone

Protein Structure and Domains

PDB ID

InterPro

IPR000219 Dbl homology (DH) domain
IPR001478 PDZ domain
IPR001849 Pleckstrin homology domain
IPR003116 Raf-like Ras-binding
IPR029071 Ubiquitin-related domain

PFAM

PF00621
PF00595
PF13180
PF00169
PF02196

PRINTS

PIRSF

SMART

SM00325
SM00228
SM00233
SM00455

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q13009