InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Gstz1

Summary

InnateDB Protein

IDBP-159930.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gstz1

Protein Name

glutathione transferase zeta 1 (maleylacetoacetate isomerase)

Synonyms

MAAI;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000053540

InnateDB Gene

IDBG-159928 (Gstz1)

Protein Structure

UniProt Annotation

Function

Probable bifunctional enzyme showing minimal glutathione-conjugating activity with ethacrynic acid and 7- chloro-4-nitrobenz-2-oxa-1, 3-diazole and maleylacetoacetate isomerase activity. Has also low glutathione peroxidase activity with t-butyl and cumene hydroperoxides. Is able to catalyze the glutathione dependent oxygenation of dichloroacetic acid to glyoxylic acid (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in liver, kidney, seminal glands and breast.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004364	glutathione transferase activity
GO:0005515	protein binding
GO:0016034	maleylacetoacetate isomerase activity
GO:0042803	protein homodimerization activity

Biological Process

GO:0006559	L-phenylalanine catabolic process
GO:0006572	tyrosine catabolic process
GO:0006749	glutathione metabolic process
GO:0009072	aromatic amino acid family metabolic process

Cellular Component

GO:0005737	cytoplasm
GO:0005739	mitochondrion

Protein Structure and Domains

PDB ID

MGI:1341859

InterPro

IPR004045 Glutathione S-transferase, N-terminal
IPR004046 Glutathione S-transferase, C-terminal
IPR005955 Maleylacetoacetate isomerase
IPR010987 Glutathione S-transferase, C-terminal-like
IPR012336 Thioredoxin-like fold

PFAM