InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TRMT2A

Summary

InnateDB Protein

IDBP-1605.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TRMT2A

Protein Name

TRM2 tRNA methyltransferase 2 homolog A (S. cerevisiae)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000252136

InnateDB Gene

IDBG-1603 (TRMT2A)

Protein Structure

UniProt Annotation

Function

May be involved in nucleic acid metabolism and/or modifications.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 42 experimentally validated interaction(s) in this database.

Experimentally validated
Total	42 [view]
Protein-Protein	42 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0004719	protein-L-isoaspartate (D-aspartate) O-methyltransferase activity
GO:0008168	methyltransferase activity
GO:0008173	RNA methyltransferase activity
GO:0008176	tRNA (guanine-N7-)-methyltransferase activity
GO:0044822	poly(A) RNA binding

Biological Process

GO:0001510	RNA methylation
GO:0006396	RNA processing
GO:0006400	tRNA modification
GO:0006464	cellular protein modification process
GO:0008152	metabolic process
GO:0031167	rRNA methylation

Cellular Component

Protein Structure and Domains

PDB ID

InterPro

IPR000241 Putative RNA methylase domain
IPR000504 RNA recognition motif domain
IPR000682 Protein-L-isoaspartate(D-aspartate) O-methyltransferase
IPR003358 tRNA (guanine-N-7) methyltransferase
IPR004033 UbiE/COQ5 methyltransferase
IPR004398 RNA methyltransferase, RsmD
IPR007848 Methyltransferase small domain
IPR010280 (Uracil-5)-methyltransferase family
IPR013216 Methyltransferase type 11
IPR029063 S-adenosyl-L-methionine-dependent methyltransferase-like

PFAM