Version 5.4
| Mus musculus Protein: Fbp2 | |||||||||
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| Summary | |||||||||
| InnateDB Protein | IDBP-160584.6 | ||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
| Gene Symbol | Fbp2 | ||||||||
| Protein Name | fructose bisphosphatase 2 | ||||||||
| Synonyms | Fbp-1; Fbp1; Rae-30; | ||||||||
| Species | Mus musculus | ||||||||
| Ensembl Protein | ENSMUSP00000021907 | ||||||||
| InnateDB Gene | IDBG-160582 (Fbp2) | ||||||||
| Protein Structure |
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| UniProt Annotation | |||||||||
| Function | Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations and probably participates in glycogen synthesis from carbohydrate precursors, such as lactate. {ECO:0000269PubMed:8034042}. | ||||||||
| Subcellular Localization | Cell junction {ECO:0000250}. Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Cytoplasm, myofibril, sarcomere, Z line {ECO:0000250}. Note=In neonatal cardiomyocytes, distributed throughout the cytosol, accumulating in the intercalated disks which occur at the Z line of cardiomyocytes and connect adjacent cells, and also located in the nucleus; dissociates from the Z line following an increase in cytosolic Ca(2+) concentration. In muscle precursor cells, localizes predominantly to the nucleus and to a lesser extent to the cytoplasm at the proliferative phase, while mainly localizing to the cytoplasm at the differentiation phase. Colocalizes with ALDOA and alpha-actinin on both sides of the Z line of skeletal muscle; dissociates rapidly from the Z line following an increase in cytosolic Ca(2+) concentration. {ECO:0000250}. | ||||||||
| Disease Associations | |||||||||
| Tissue Specificity | Expressed in muscle, intestine, brain and placenta and very weakly in liver. {ECO:0000269PubMed:11250076, ECO:0000269PubMed:8034042}. | ||||||||
| Comments | |||||||||
| Interactions | |||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Protein Structure and Domains | |||||||||
| PDB ID | MGI:95491 | ||||||||
| InterPro |
IPR000146
Fructose-1,6-bisphosphatase class 1/Sedoheputulose-1,7-bisphosphatase IPR000760 Inositol monophosphatase IPR023079 Sedoheptulose-1,7-bisphosphatase IPR028343 Fructose-1,6-bisphosphatase |
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| PFAM |
PF00316
PF00459 |
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| PRINTS |
PR00377
PR01958 PR00115 |
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| PIRSF |
PIRSF000904
PIRSF500210 |
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| SMART | |||||||||
| TIGRFAMs | |||||||||
| Post-translational Modifications | |||||||||
| Modification | |||||||||
| Cross-References | |||||||||
| SwissProt | P70695 | ||||||||
| PhosphoSite | PhosphoSite-P70695 | ||||||||
| TrEMBL | Q3TKP4 | ||||||||
| UniProt Splice Variant | |||||||||
| Entrez Gene | 14120 | ||||||||
| UniGene | Mm.391871 | ||||||||
| RefSeq | NP_032020 | ||||||||
| MGI ID | |||||||||
| MGI Symbol | Fbp2 | ||||||||
| OMIM | |||||||||
| CCDS | CCDS36698 | ||||||||
| HPRD | |||||||||
| IMGT | |||||||||
| EMBL | AJ132692 AJ243020 AJ243021 AJ243022 AJ243023 AJ243024 AJ243025 AJ243026 AJ243027 AJ243028 AJ245381 AJ245382 AJ245383 AK146946 AK166898 AK166973 BC012720 CH466631 D42083 | ||||||||
| GenPept | AAH12720 BAA07678 BAE27555 BAE39101 BAE39156 CAB65243 CAB65260 CAB65261 CAB65262 CAB90667 CAB90668 CAB90669 CAB90670 CAB90671 CAB90672 CAB90673 CAB90674 CAB90675 EDL16209 | ||||||||