InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Eng

Summary

InnateDB Protein

IDBP-160785.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Eng

Protein Name

endoglin

Synonyms

AI528660; AI662476; CD105; Endo; S-endoglin;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000009705

InnateDB Gene

IDBG-160783 (Eng)

Protein Structure

UniProt Annotation

Function

Major glycoprotein of vascular endothelium. Involved in the regulation of angiogenesis. May play a critical role in the binding of endothelial cells to integrins and/or other RGD receptors. Acts as TGF-beta coreceptor and is involved in the TGF- beta/BMP signaling cascade. Required for GDF2/BMP9 signaling through SMAD1 in endothelial cells. {ECO:0000269PubMed:23300529}.

Subcellular Localization

Membrane; Single-pass type I membrane protein.

Disease Associations

Tissue Specificity

Endoglin is restricted to endothelial cells in all tissues except bone marrow and is also found in stromal cells within the connective tissue of intestine, stomach, heart, skeletal muscle, uterus, ovary, oviduct, testis and thymus.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	18 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005024	transforming growth factor beta-activated receptor activity
GO:0005072	transforming growth factor beta receptor, cytoplasmic mediator activity
GO:0005114	type II transforming growth factor beta receptor binding
GO:0005515	protein binding
GO:0005534	galactose binding
GO:0005539	glycosaminoglycan binding
GO:0034713	type I transforming growth factor beta receptor binding
GO:0042803	protein homodimerization activity
GO:0050431	transforming growth factor beta binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001300	chronological cell aging
GO:0001525	angiogenesis
GO:0001569	patterning of blood vessels
GO:0001570	vasculogenesis
GO:0001666	response to hypoxia
GO:0001934	positive regulation of protein phosphorylation
GO:0001937	negative regulation of endothelial cell proliferation
GO:0001947	heart looping
GO:0003084	positive regulation of systemic arterial blood pressure
GO:0003273	cell migration involved in endocardial cushion formation
GO:0006355	regulation of transcription, DNA-templated
GO:0007155	cell adhesion
GO:0007179	transforming growth factor beta receptor signaling pathway
GO:0007507	heart development
GO:0010628	positive regulation of gene expression
GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0016477	cell migration
GO:0017015	regulation of transforming growth factor beta receptor signaling pathway
GO:0022009	central nervous system vasculogenesis
GO:0022617	extracellular matrix disassembly
GO:0030336	negative regulation of cell migration
GO:0030513	positive regulation of BMP signaling pathway
GO:0031953	negative regulation of protein autophosphorylation
GO:0031960	response to corticosteroid
GO:0032967	positive regulation of collagen biosynthetic process
GO:0035556	intracellular signal transduction
GO:0036273	response to statin
GO:0042060	wound healing
GO:0045766	positive regulation of angiogenesis
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048745	smooth muscle tissue development
GO:0048844	artery morphogenesis
GO:0048845	venous blood vessel morphogenesis
GO:0048870	cell motility
GO:0051001	negative regulation of nitric-oxide synthase activity
GO:0060326	cell chemotaxis
GO:0060348	bone development
GO:0060394	negative regulation of pathway-restricted SMAD protein phosphorylation
GO:0070278	extracellular matrix constituent secretion
GO:0070483	detection of hypoxia
GO:0071260	cellular response to mechanical stimulus
GO:0071559	response to transforming growth factor beta

Cellular Component

GO:0005615	extracellular space
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0009897	external side of plasma membrane
GO:0009986	cell surface
GO:0016021	integral component of membrane
GO:0072563	endothelial microparticle