InnateDB Protein
|
IDBP-161065.6
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
Slc7a7
|
Protein Name
|
solute carrier family 7 (cationic amino acid transporter, y+ system), member 7
|
Synonyms
|
AI790233; my+lat1;
|
Species
|
Mus musculus
|
Ensembl Protein
|
ENSMUSP00000000984
|
InnateDB Gene
|
IDBG-161063 (Slc7a7)
|
Protein Structure
|
|
Function |
Involved in the sodium-independent uptake of dibasic amino acids and sodium-dependent uptake of some neutral amino acids. Requires coexpression with SLC3A2/4F2hc to mediate the uptake of arginine, leucine and glutamine. Plays a role in nitric oxide synthesis via transport of L-arginine, and is involved in the transport of L-arginine in monocytes. {ECO:0000269PubMed:9878049}.
|
Subcellular Localization |
Basolateral cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
|
Disease Associations |
|
Tissue Specificity |
Strongly expressed in kidney and intestine. Weaker expression observed in epididymis, testis, ovary, thyroid pancreas, sub-gland and liver. {ECO:0000269PubMed:9878049}.
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated |
Total |
1
[view]
|
Protein-Protein |
1
[view]
|
Protein-DNA |
0
|
Protein-RNA |
0
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
Predicted by orthology |
Total |
2 [view]
|
|
|
Molecular Function |
Accession |
GO Term |
GO:0015171
|
amino acid transmembrane transporter activity
|
|
Biological Process |
|
Cellular Component |
|
PDB ID |
MGI:1337120
|
InterPro |
IPR002293
Amino acid/polyamine transporter I
IPR004841
Amino acid permease/ SLC12A domain
|
PFAM |
PF13520
PF00324
|
PRINTS |
|
PIRSF |
PIRSF006060
|
SMART |
|
TIGRFAMs |
|
Modification |
|
SwissProt |
Q9Z1K8
|
PhosphoSite |
PhosphoSite-Q9Z1K8
|
TrEMBL |
|
UniProt Splice Variant |
|
Entrez Gene |
20540
|
UniGene |
|
RefSeq |
NP_035535
|
MGI ID |
|
MGI Symbol |
Slc7a7
|
OMIM |
|
CCDS |
CCDS27087
|
HPRD |
|
IMGT |
|
EMBL |
AJ012754
AJ130943
AK150950
AK151718
AK152637
AK170851
BC014709
|
GenPept |
AAH14709
BAE29983
BAE30637
BAE31379
BAE42073
CAA10170
CAA10255
|
|
|