InnateDB Protein
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IDBP-161605.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Glo1
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Protein Name
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glyoxalase 1
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Synonyms
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0610009E22Rik; 1110008E19Rik; 2510049H23Rik; AW550643; Glo-1; Glo-1r; Glo-1s; Glo1-r; Glo1-s; GLY1; Qglo;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000024823
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InnateDB Gene
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IDBG-161603 (Glo1)
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Protein Structure
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Function |
Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. Involved in the regulation of TNF-induced transcriptional activity of NF- kappa-B. Required for normal osteoclastogenesis. {ECO:0000269PubMed:18695250}.
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Subcellular Localization |
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated |
Total |
11
[view]
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Protein-Protein |
11
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
7 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:95742
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InterPro |
IPR004360
Glyoxalase/fosfomycin resistance/dioxygenase domain
IPR004361
Glyoxalase I
IPR029068
Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase
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PFAM |
PF00903
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9CPU0
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PhosphoSite |
PhosphoSite-Q9CPU0
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TrEMBL |
A5GZX3
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UniProt Splice Variant |
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Entrez Gene |
109801
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UniGene |
Mm.472992
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RefSeq |
NP_079650
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MGI ID |
4KYK
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MGI Symbol |
Glo1
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OMIM |
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CCDS |
CCDS28600
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HPRD |
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IMGT |
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EMBL |
AK002386
AK003567
AK005055
AK031832
AK049703
BC024663
BC081432
CH466542
DQ487161
DQ487162
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GenPept |
AAH24663
AAH81432
ABF48483
ABF48484
BAB22060
BAB22863
BAB23781
BAC27570
BAC33882
EDL08651
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