InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cisd1

Summary

InnateDB Protein

IDBP-161779.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cisd1

Protein Name

CDGSH iron sulfur domain 1

Synonyms

AU043990; AW743335; D10Ertd214e; mitoNEET; Zcd1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000043559

InnateDB Gene

IDBG-161777 (Cisd1)

Protein Structure

UniProt Annotation

Function

Plays a key role in regulating maximal capacity for electron transport and oxidative phosphorylation. May be involved in Fe-S cluster shuttling and/or in redox reactions (By similarity). {ECO:0000250}.

Subcellular Localization

Mitochondrion outer membrane {ECO:0000269PubMed:17376863}; Single-pass type III membrane protein {ECO:0000269PubMed:17376863}.

Disease Associations

Tissue Specificity

Liver, adipose, skeletal muscle and heart (at protein level). Widely expressed. Expressed at the highest levels in the heart. {ECO:0000269PubMed:17376863}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	11 [view]
Protein-Protein	11 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005506	iron ion binding
GO:0051537	2 iron, 2 sulfur cluster binding

Biological Process

GO:0043457

regulation of cellular respiration

Cellular Component

GO:0005739	mitochondrion
GO:0005741	mitochondrial outer membrane
GO:0016021	integral component of membrane
GO:0043231	intracellular membrane-bounded organelle
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:1261855

InterPro

IPR006622 Iron sulphur-containing domain, CDGSH-type, subfamily
IPR018967 Iron sulphur-containing domain, CDGSH-type
IPR019610 Iron sulphur domain-containing, mitoNEET, N-terminal

PFAM

PF09360
PF10660

PRINTS

PIRSF

SMART

SM00704

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q91WS0