InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ifnb1

Summary

InnateDB Protein

IDBP-162200.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ifnb1

Protein Name

interferon beta 1, fibroblast

Synonyms

Ifb; IFN-beta; IFNB;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000056720

InnateDB Gene

IDBG-162198 (Ifnb1)

Protein Structure

UniProt Annotation

Function

Has antiviral, antibacterial and anticancer activities.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 29 experimentally validated interaction(s) in this database.
They are also associated with 29 interaction(s) predicted by orthology.

Experimentally validated
Total	29 [view]
Protein-Protein	0
Protein-DNA	28 [view]
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	29 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003714	transcription corepressor activity
GO:0005125	cytokine activity
GO:0005126	cytokine receptor binding
GO:0005132	type I interferon receptor binding

Biological Process

GO:0002250	adaptive immune response
GO:0002286	T cell activation involved in immune response
GO:0002312	B cell activation involved in immune response
GO:0002323	natural killer cell activation involved in immune response
GO:0006952	defense response
GO:0006959	humoral immune response
GO:0019221	cytokine-mediated signaling pathway
GO:0030183	B cell differentiation
GO:0032897	negative regulation of viral transcription
GO:0033141	positive regulation of peptidyl-serine phosphorylation of STAT protein
GO:0035458	cellular response to interferon-beta
GO:0042100	B cell proliferation
GO:0042742	defense response to bacterium
GO:0043330	response to exogenous dsRNA
GO:0045071	negative regulation of viral genome replication
GO:0045087	innate immune response (InnateDB)
GO:0045343	regulation of MHC class I biosynthetic process
GO:0045581	negative regulation of T cell differentiation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0051607	defense response to virus
GO:0060337	type I interferon signaling pathway
GO:0071359	cellular response to dsRNA
GO:0071360	cellular response to exogenous dsRNA
GO:0097194	execution phase of apoptosis
GO:2000552	negative regulation of T-helper 2 cell cytokine production
GO:2001235	positive regulation of apoptotic signaling pathway