InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Josd1

Summary

InnateDB Protein

IDBP-162331.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Josd1

Protein Name

Josephin domain containing 1

Synonyms

1300006C06Rik; mKIAA0063;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000023061

InnateDB Gene

IDBG-162329 (Josd1)

Protein Structure

UniProt Annotation

Function

Deubiquitinates monoubiquitinated probes (in vitro). When ubiquitinated, cleaves 'Lys-63'-linked and 'Lys-48'-linked poly-ubiquitin chains (in vitro), hence may act as a deubiquitinating enzyme. May increase macropinocytosis and suppress clathrin- and caveolae-mediated endocytosis. May enhance membrane dynamics and cell motility independently of its catalytic activity (By similarity). {ECO:0000250}.

Subcellular Localization

Cell membrane {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=Ubiquitination increases localization the plasma membrane. In the cytosol, the unubiquitinated form may be associated with the cytoskeleton via ACTB-binding. {ECO:0000250}.

Disease Associations

Tissue Specificity

Widely expressed (at protein level). {ECO:0000269PubMed:23625928}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008242	omega peptidase activity

Biological Process

GO:0006508

proteolysis

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0016020	membrane

Protein Structure and Domains

PDB ID

MGI:1921408

InterPro

IPR006155 Machado-Joseph disease protein MJD

PFAM

PF02099

PRINTS

PR01233

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9DBJ6

PhosphoSite

PhosphoSite-Q9DBJ6

TrEMBL

UniProt Splice Variant

Entrez Gene

74158

UniGene

Mm.489913

RefSeq

NP_083068

MGI ID

MGI Symbol

Josd1

OMIM

CCDS

CCDS27647

HPRD

IMGT

EMBL

AK004913 AK154799 BC006928 BC086769

GenPept

AAH06928 AAH86769 BAB23664 BAE32837