InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cope

Summary

InnateDB Protein

IDBP-162494.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cope

Protein Name

coatomer protein complex, subunit epsilon

Synonyms

1110005D17Rik; Cope1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000071078

InnateDB Gene

IDBG-162492 (Cope)

Protein Structure

UniProt Annotation

Function

The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non- clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated with ADP- ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cytoplasmic vesicle, COPI-coated vesicle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	18 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005198	structural molecule activity

Biological Process

GO:0006890	retrograde vesicle-mediated transport, Golgi to ER
GO:0015031	protein transport

Cellular Component

GO:0005634	nucleus
GO:0005794	Golgi apparatus
GO:0030137	COPI-coated vesicle
GO:0030663	COPI-coated vesicle membrane

Protein Structure and Domains

PDB ID

MGI:1891702

InterPro

IPR006822 Coatomer, epsilon subunit

PFAM

PF04733

PRINTS

PIRSF

PIRSF016478

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O89079

PhosphoSite

PhosphoSite-O89079

TrEMBL

UniProt Splice Variant

Entrez Gene

59042

UniGene

Mm.28668

RefSeq

NP_067513

MGI ID

MGI Symbol

Cope

OMIM

CCDS

CCDS22365

HPRD

IMGT

EMBL

AB039837 BC009170 BC083336 U89427

GenPept

AAC36533 AAH09170 AAH83336 BAA92384