InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MNT

Summary

InnateDB Protein

IDBP-16291.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MNT

Protein Name

MAX binding protein

Synonyms

bHLHd3; MAD6; MXD6; ROX;

Species

Homo sapiens

Ensembl Protein

ENSP00000174618

InnateDB Gene

IDBG-16287 (MNT)

Protein Structure

UniProt Annotation

Function

Binds DNA as a heterodimer with MAX and represses transcription. Binds to the canonical E box sequence 5'-CACGTG-3' and, with higher affinity, to 5'-CACGCG-3'.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	13 [view]
Protein-Protein	13 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding
GO:0001227	RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003713	transcription coactivator activity
GO:0003714	transcription corepressor activity
GO:0005515	protein binding
GO:0046983	protein dimerization activity

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0007275	multicellular organismal development
GO:0007569	cell aging
GO:0008285	negative regulation of cell proliferation
GO:0051726	regulation of cell cycle
GO:2001234	negative regulation of apoptotic signaling pathway