InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Nrl

Summary

InnateDB Protein

IDBP-163871.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Nrl

Protein Name

neural retina leucine zipper gene

Synonyms

D14H14S46E;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000054457

InnateDB Gene

IDBG-163869 (Nrl)

Protein Structure

UniProt Annotation

Function

Transcription factor which regulates the expression of several rod-specific genes, in cluding RHO and PDE6B. {ECO:0000250}.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Neural retina.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0043522	leucine zipper domain binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007468	regulation of rhodopsin gene expression
GO:0045872	positive regulation of rhodopsin gene expression
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046548	retinal rod cell development

Cellular Component

GO:0005634

nucleus

Protein Structure and Domains

PDB ID

MGI:102567

InterPro

IPR004826 Basic leucine zipper domain, Maf-type
IPR004827 Basic-leucine zipper domain
IPR008917 Transcription factor, Skn-1-like, DNA-binding domain
IPR013592 Maf transcription factor, N-terminal

PFAM

PF03131
PF00170
PF07716
PF08383

PRINTS

PIRSF

SMART

SM00338

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P54846