Mus musculus Protein: Mtrr | |||||||||||||||||
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Summary | |||||||||||||||||
InnateDB Protein | IDBP-164390.7 | ||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||
Gene Symbol | Mtrr | ||||||||||||||||
Protein Name | 5-methyltetrahydrofolate-homocysteine methyltransferase reductase | ||||||||||||||||
Synonyms | |||||||||||||||||
Species | Mus musculus | ||||||||||||||||
Ensembl Protein | ENSMUSP00000039810 | ||||||||||||||||
InnateDB Gene | IDBG-164388 (Mtrr) | ||||||||||||||||
Protein Structure | |||||||||||||||||
UniProt Annotation | |||||||||||||||||
Function | Involved in the reductive regeneration of cob(I)alamin (vitamin B12) cofactor required for the maintenance of methionine synthase in a functional state. Necessary for utilization of methylgroups from the folate cycle, thereby affecting transgenerational epigenetic inheritance. Folate pathway donates methyl groups necessary for cellular methylation and affects different pathways such as DNA methylation, possibly explaining the transgenerational epigenetic inheritance effects. {ECO:0000269PubMed:24074862}. | ||||||||||||||||
Subcellular Localization | Cytoplasm {ECO:0000250}. | ||||||||||||||||
Disease Associations | |||||||||||||||||
Tissue Specificity | |||||||||||||||||
Comments | |||||||||||||||||
Interactions | |||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||||||
PDB ID | MGI:1891037 | ||||||||||||||||
InterPro |
IPR001094
Flavodoxin IPR001433 Oxidoreductase FAD/NAD(P)-binding IPR001709 Flavoprotein pyridine nucleotide cytochrome reductase IPR003097 FAD-binding, type 1 IPR008254 Flavodoxin/nitric oxide synthase IPR017938 Riboflavin synthase-like beta-barrel IPR029039 Flavoprotein-like |
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PFAM |
PF00175
PF00667 PF00258 |
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PRINTS |
PR00369
PR00371 |
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PIRSF | |||||||||||||||||
SMART | |||||||||||||||||
TIGRFAMs | |||||||||||||||||
Post-translational Modifications | |||||||||||||||||
Modification | |||||||||||||||||
Cross-References | |||||||||||||||||
SwissProt | Q8C1A3 | ||||||||||||||||
PhosphoSite | PhosphoSite-Q8C1A3 | ||||||||||||||||
TrEMBL | |||||||||||||||||
UniProt Splice Variant | |||||||||||||||||
Entrez Gene | 210009 | ||||||||||||||||
UniGene | Mm.490108 | ||||||||||||||||
RefSeq | NP_766068 | ||||||||||||||||
MGI ID | |||||||||||||||||
MGI Symbol | Mtrr | ||||||||||||||||
OMIM | |||||||||||||||||
CCDS | CCDS26620 | ||||||||||||||||
HPRD | |||||||||||||||||
IMGT | |||||||||||||||||
EMBL | AK028628 AK155359 AK163449 BC025942 CH466563 | ||||||||||||||||
GenPept | AAH25942 BAC26039 BAE33215 BAE37348 EDL37004 | ||||||||||||||||