InnateDB Protein
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IDBP-166213.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Gnb2l1
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Protein Name
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guanine nucleotide binding protein (G protein), beta polypeptide 2 like 1
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Synonyms
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AL033335; GB-like; Gnb2-rs1; p205; Rack1;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000020640
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InnateDB Gene
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IDBG-166211 (Gnb2l1)
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Protein Structure
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Function |
Involved in the recruitment, assembly and/or regulation of a variety of signaling molecules. Interacts with a wide variety of proteins and plays a role in many cellular processes. Component of the 40S ribosomal subunit involved in translational repression. Binds to and stabilizes activated protein kinase C (PKC), increasing PKC-mediated phosphorylation. May recruit activated PKC to the ribosome, leading to phosphorylation of EIF6. Inhibits the activity of SRC kinases including SRC, LCK and YES1. Inhibits cell growth by prolonging the G0/G1 phase of the cell cycle. Enhances phosphorylation of BMAL1 by PRKCA and inhibits transcriptional activity of the BMAL1-CLOCK heterodimer. Facilitates ligand- independent nuclear translocation of AR following PKC activation, represses AR transactivation activity and is required for phosphorylation of AR by SRC. Modulates IGF1R-dependent integrin signaling and promotes cell spreading and contact with the extracellular matrix. Involved in PKC-dependent translocation of ADAM12 to the cell membrane. Promotes the ubiquitination and proteasome-mediated degradation of proteins such as CLEC1B and HIF1A. Required for VANGL2 membrane localization, inhibits Wnt signaling, and regulates cellular polarization and oriented cell division during gastrulation. Required for PTK2/FAK1 phosphorylation and dephosphorylation. Regulates internalization of the muscarinic receptor CHRM2. Promotes apoptosis by increasing oligomerization of BAX and disrupting the interaction of BAX with the anti-apoptotic factor BCL2L. Inhibits TRPM6 channel activity. Regulates cell surface expression of some GPCRs such as TBXA2R. Plays a role in regulation of FLT1-mediated cell migration. {ECO:0000269PubMed:18258429, ECO:0000269PubMed:20093473, ECO:0000269PubMed:7968370}.
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Subcellular Localization |
Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cytoplasm {ECO:0000250}. Cytoplasm, perinuclear region {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Nucleus. Perikaryon. Cell projection, dendrite. Note=Recruited to the plasma membrane through interaction with KRT1 which binds to membrane-bound ITGB1. PKC activation induces translocation from the perinuclear region to the cell periphery. In the brain, detected mainly in cell bodies and dendrites with little expression in axonal fibers or nuclei (By similarity). {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Strongly and ubiquitously expressed in the embryonic and early postnatal brain. At E11.5, expressed in a high-dorsal to low-ventral gradient throughout the brain. At E13.5, most abundant in the telecephalon. At E18.5, expressed most abundantly in layers 1-4 of the cortex, striatum, hippocampus, dentate gyrus, and specific thalamic nuclei. This expression decreases during postnatal development and is localized in the dentate gyrus, habenula, piriform cortex, paraventricular nucleus of the hypothalamus and supraoptic nucleus of the adult brain. {ECO:0000269PubMed:16414032, ECO:0000269PubMed:7968370}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 44 experimentally validated interaction(s) in this database.
They are also associated with 129 interaction(s) predicted by orthology.
Experimentally validated |
Total |
44
[view]
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Protein-Protein |
44
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
129 [view]
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Molecular Function |
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Biological Process |
GO:0001649
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osteoblast differentiation
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GO:0001934
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positive regulation of protein phosphorylation
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GO:0006919
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activation of cysteine-type endopeptidase activity involved in apoptotic process
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GO:0007049
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cell cycle
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GO:0007369
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gastrulation
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GO:0008104
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protein localization
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GO:0010629
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negative regulation of gene expression
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GO:0017148
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negative regulation of translation
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GO:0030178
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negative regulation of Wnt signaling pathway
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GO:0030308
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negative regulation of cell growth
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GO:0030335
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positive regulation of cell migration
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GO:0030822
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positive regulation of cAMP catabolic process
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GO:0032436
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positive regulation of proteasomal ubiquitin-dependent protein catabolic process
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GO:0032464
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positive regulation of protein homooligomerization
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GO:0032880
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regulation of protein localization
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GO:0035556
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intracellular signal transduction
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GO:0043065
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positive regulation of apoptotic process
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GO:0043524
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negative regulation of neuron apoptotic process
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GO:0043547
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positive regulation of GTPase activity
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GO:0048511
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rhythmic process
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GO:0050765
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negative regulation of phagocytosis
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GO:0051302
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regulation of cell division
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GO:0051343
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positive regulation of cyclic-nucleotide phosphodiesterase activity
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GO:0051726
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regulation of cell cycle
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GO:0051898
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negative regulation of protein kinase B signaling
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GO:0051901
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positive regulation of mitochondrial depolarization
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GO:0061099
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negative regulation of protein tyrosine kinase activity
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GO:0090003
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regulation of establishment of protein localization to plasma membrane
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GO:1901299
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negative regulation of hydrogen peroxide-mediated programmed cell death
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GO:2000114
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regulation of establishment of cell polarity
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GO:2000543
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positive regulation of gastrulation
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GO:2001244
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positive regulation of intrinsic apoptotic signaling pathway
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Cellular Component |
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PDB ID |
MGI:101849
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InterPro |
IPR001680
WD40 repeat
IPR017986
WD40-repeat-containing domain
IPR020472
G-protein beta WD-40 repeat
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PFAM |
PF00400
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PRINTS |
PR00320
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PIRSF |
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SMART |
SM00320
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TIGRFAMs |
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Modification |
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SwissProt |
P68040
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PhosphoSite |
PhosphoSite-P68040
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
14694
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UniGene |
Mm.396849
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RefSeq |
NP_032169
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MGI ID |
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MGI Symbol |
Gnb2l1
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OMIM |
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CCDS |
CCDS24585
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HPRD |
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IMGT |
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EMBL |
AF295529
AK002493
AK012242
AK017772
AK051226
AK159797
AK160528
AK160739
AK161234
AK166417
AK166786
AK166800
AK166889
AK166945
AK168086
AK168096
AK168196
AK168349
AL645849
BC046760
CH466575
D29802
X75313
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GenPept |
AAG29506
AAH46760
BAA06185
BAB22141
BAB28114
BAB30920
BAC34564
BAE35378
BAE35846
BAE35980
BAE36257
BAE38762
BAE39017
BAE39028
BAE39095
BAE39133
BAE40059
BAE40068
BAE40156
BAE40286
CAA53062
CAI35106
EDL33791
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