InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MTMR6

Summary

InnateDB Protein

IDBP-16674.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MTMR6

Protein Name

myotubularin related protein 6

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000371221

InnateDB Gene

IDBG-16672 (MTMR6)

Protein Structure

UniProt Annotation

Function

Phosphatase that acts on lipids with a phosphoinositol headgroup. Acts as a negative regulator of KCNN4/KCa3.1 channel activity in CD4+ T-cells possibly by decreasing intracellular levels of phosphatidylinositol 3 phosphatase. Negatively regulates proliferation of reactivated CD4+ T-cells. {ECO:0000269PubMed:15831468, ECO:0000269PubMed:16847315}.

Subcellular Localization

Nucleus envelope {ECO:0000269PubMed:16787938}.

Disease Associations

Tissue Specificity

Expressed in CD4+ T-cells. {ECO:0000269PubMed:16847315}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004722	protein serine/threonine phosphatase activity
GO:0004725	protein tyrosine phosphatase activity
GO:0015269	calcium-activated potassium channel activity
GO:0016791	phosphatase activity

Biological Process

GO:0006470	protein dephosphorylation
GO:0006644	phospholipid metabolic process
GO:0006661	phosphatidylinositol biosynthetic process
GO:0016311	dephosphorylation
GO:0035335	peptidyl-tyrosine dephosphorylation
GO:0044281	small molecule metabolic process
GO:0071805	potassium ion transmembrane transport