InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Gatad2b

Summary

InnateDB Protein

IDBP-166802.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gatad2b

Protein Name

GATA zinc finger domain containing 2B

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000041370

InnateDB Gene

IDBG-166800 (Gatad2b)

Protein Structure

UniProt Annotation

Function

Transcriptional repressor. Enhances MBD2-mediated repression. Efficient repression requires the presence of GATAD2A (By similarity). Targets MBD3 to discrete loci in the nucleus (By similarity). Plays a role in synapse development (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus speckle {ECO:0000250}. Note=Speckled nuclear localization requires both CR1 and CR2 regions. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.

Experimentally validated
Total	16 [view]
Protein-Protein	16 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	18 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0031492	nucleosomal DNA binding
GO:0043565	sequence-specific DNA binding