InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TLE2

Summary

InnateDB Protein

IDBP-16682.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TLE2

Protein Name

transducin-like enhancer of split 2 (E(sp1) homolog, Drosophila)

Synonyms

ESG; ESG2; GRG2;

Species

Homo sapiens

Ensembl Protein

ENSP00000262953

InnateDB Gene

IDBG-16680 (TLE2)

Protein Structure

UniProt Annotation

Function

Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

In all tissues examined, mostly in heart, brain, and muscle.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.

Experimentally validated
Total	19 [view]
Protein-Protein	19 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003714	transcription corepressor activity
GO:0005515	protein binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0007165	signal transduction
GO:0007219	Notch signaling pathway
GO:0009887	organ morphogenesis
GO:0016055	Wnt signaling pathway
GO:0045892	negative regulation of transcription, DNA-templated
GO:0090090	negative regulation of canonical Wnt signaling pathway

Cellular Component

GO:0005615	extracellular space
GO:0005634	nucleus
GO:0005654	nucleoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR001680 WD40 repeat
IPR005617 Groucho/TLE, N-terminal Q-rich domain
IPR009146 Groucho/transducin-like enhancer
IPR017986 WD40-repeat-containing domain

PFAM

PF00400
PF03920

PRINTS

PR01850

PIRSF

SMART

SM00320

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt