Version 5.4
Mus musculus Protein: Nit2
Summary
InnateDB Protein IDBP-168527.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Nit2
Protein Name nitrilase family, member 2
Synonyms 1190017B19Rik; D16Ertd502e;
Species Mus musculus
Ensembl Protein ENSMUSP00000023432
InnateDB Gene IDBG-168525 (Nit2)
Protein Structure
UniProt Annotation
Function Has a omega-amidase activity. The role of omega-amidase is to remove potentially toxic intermediates by converting alpha- ketoglutaramate and alpha-ketosuccinamate to biologically useful alpha-ketoglutarate and oxaloacetate, respectively. {ECO:0000269PubMed:19596042}.
Subcellular Localization Cytoplasm {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 15 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
GO:0050152 omega-amidase activity
Biological Process
GO:0006107 oxaloacetate metabolic process
GO:0006528 asparagine metabolic process
GO:0006541 glutamine metabolic process
GO:0006807 nitrogen compound metabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005813 centrosome
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID MGI:1261838
InterPro IPR003010 Carbon-nitrogen hydrolase
PFAM PF00795
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9JHW2
PhosphoSite PhosphoSite-Q9JHW2
TrEMBL
UniProt Splice Variant
Entrez Gene 52633
UniGene
RefSeq NP_075664
MGI ID 2W1V
MGI Symbol Nit2
OMIM
CCDS CCDS37363
HPRD
IMGT
EMBL AF284573 AK003604 AK004535 BC020153
GenPept AAF87102 AAH20153 BAB22884 BAB23354

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca