InnateDB Protein
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IDBP-168954.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Klf15
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Protein Name
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Kruppel-like factor 15
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Synonyms
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1810013I09Rik; AV048136; AW494632; CKLF; KKLF;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000032174
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InnateDB Gene
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IDBG-168952 (Klf15)
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Protein Structure
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Function |
Transcriptional regulator that binds to the GA element of the CLCNKA promoter (By similarity). Binds to the KCNIP2 promoter and regulates KCNIP2 circadian expression in the heart. Is a repressor of CTGF expression, involved in the control of cardiac fibrosis. Is also involved in the control of cardiac hypertrophy acting through the inhibition of MEF2A, GATA4 and MYOCD activity. Is a negative regulator of TP53 acetylation. Inhibits NF-kappa-B activation through repression of EP300- dependent RELA acetylation (By similarity). Involved in podocyte differentiation. {ECO:0000250, ECO:0000269PubMed:17438289, ECO:0000269PubMed:18586263, ECO:0000269PubMed:20375365, ECO:0000269PubMed:20566642, ECO:0000269PubMed:22367544, ECO:0000269PubMed:22493483, ECO:0000269PubMed:23999430}.
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Subcellular Localization |
Nucleus.
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Disease Associations |
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Tissue Specificity |
Expressed in aortic smooth muscle cells. {ECO:0000269PubMed:23999430}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
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Predicted by orthology |
Total |
4 [view]
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Molecular Function |
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Biological Process |
GO:0006351
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transcription, DNA-templated
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GO:0010001
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glial cell differentiation
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GO:0010468
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regulation of gene expression
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GO:0014898
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cardiac muscle hypertrophy in response to stress
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GO:0015758
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glucose transport
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GO:0045893
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positive regulation of transcription, DNA-templated
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GO:0045944
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positive regulation of transcription from RNA polymerase II promoter
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GO:0072112
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glomerular visceral epithelial cell differentiation
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GO:1901653
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cellular response to peptide
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GO:2000757
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negative regulation of peptidyl-lysine acetylation
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Cellular Component |
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PDB ID |
MGI:1929988
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InterPro |
IPR007087
Zinc finger, C2H2
IPR015880
Zinc finger, C2H2-like
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PFAM |
PF00096
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PRINTS |
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PIRSF |
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SMART |
SM00355
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TIGRFAMs |
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Modification |
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SwissProt |
Q9EPW2
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PhosphoSite |
PhosphoSite-Q9EPW2
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
66277
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UniGene |
Mm.41389
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RefSeq |
NP_075673
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MGI ID |
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MGI Symbol |
Klf15
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OMIM |
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CCDS |
CCDS20360
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HPRD |
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IMGT |
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EMBL |
AF317225
AK009739
AK142618
BC013486
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GenPept |
AAG38597
AAH13486
BAB26470
BAE25132
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