InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GNA15

Summary

InnateDB Protein

IDBP-16919.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GNA15

Protein Name

guanine nucleotide binding protein (G protein), alpha 15 (Gq class)

Synonyms

GNA16;

Species

Homo sapiens

Ensembl Protein

ENSP00000262958

InnateDB Gene

IDBG-16917 (GNA15)

Protein Structure

UniProt Annotation

Function

Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.

Subcellular Localization

Disease Associations

Tissue Specificity

Specifically expressed in hematopoietic cells. Expressed in epididymis (at protein level). {ECO:0000269PubMed:20736409}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.

Experimentally validated
Total	12 [view]
Protein-Protein	12 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001664	G-protein coupled receptor binding
GO:0003924	GTPase activity
GO:0004871	signal transducer activity
GO:0005525	GTP binding
GO:0019001	guanyl nucleotide binding
GO:0031683	G-protein beta/gamma-subunit complex binding
GO:0046872	metal ion binding

Biological Process

GO:0006184	GTP catabolic process
GO:0007165	signal transduction
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007188	adenylate cyclase-modulating G-protein coupled receptor signaling pathway
GO:0007200	phospholipase C-activating G-protein coupled receptor signaling pathway
GO:0007202	activation of phospholipase C activity
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0007207	phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway
GO:0007596	blood coagulation
GO:0030168	platelet activation
GO:0060158	phospholipase C-activating dopamine receptor signaling pathway

Cellular Component

GO:0005834	heterotrimeric G-protein complex
GO:0005886	plasma membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000654 G-protein alpha subunit, group Q
IPR001019 Guanine nucleotide binding protein (G-protein), alpha subunit
IPR006689 Small GTPase superfamily, ARF/SAR type
IPR011025 G protein alpha subunit, helical insertion
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00503
PF00025

PRINTS

PR00442
PR00318
PR00328

PIRSF

SMART

SM00275

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt