InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Pkd2l1

Summary

InnateDB Protein

IDBP-169470.5

Last Modified

2012-02-14 [Report errors or provide feedback]

Gene Symbol

Pkd2l1

Protein Name

polycystic kidney disease 2-like 1

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000045675

InnateDB Gene

IDBG-169468 (Pkd2l1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005216	ion channel activity
GO:0005227	calcium activated cation channel activity
GO:0005261	cation channel activity
GO:0005262	calcium channel activity
GO:0005272	sodium channel activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0008092	cytoskeletal protein binding
GO:0008324	cation transmembrane transporter activity
GO:0015269	calcium-activated potassium channel activity
GO:0033040	sour taste receptor activity
GO:0042802	identical protein binding
GO:0051371	muscle alpha-actinin binding
GO:0051393	alpha-actinin binding

Biological Process

GO:0001581	detection of chemical stimulus involved in sensory perception of sour taste
GO:0006811	ion transport
GO:0006812	cation transport
GO:0007224	smoothened signaling pathway
GO:0035725	sodium ion transmembrane transport
GO:0050915	sensory perception of sour taste
GO:0050982	detection of mechanical stimulus
GO:0055085	transmembrane transport
GO:0070207	protein homotrimerization
GO:0070588	calcium ion transmembrane transport
GO:0071468	cellular response to acidity
GO:0071805	potassium ion transmembrane transport

Cellular Component

GO:0005783	endoplasmic reticulum
GO:0005886	plasma membrane
GO:0009986	cell surface
GO:0016020	membrane
GO:0031513	nonmotile primary cilium
GO:0034704	calcium channel complex
GO:0043231	intracellular membrane-bounded organelle
GO:0060170	ciliary membrane

Protein Structure and Domains

PDB ID

MGI:1352448

InterPro

IPR000434 Polycystic kidney disease type 1 protein
IPR002048 EF-hand domain
IPR003915 Polycystic kidney disease type 2 protein
IPR005821 Ion transport domain
IPR013122 Polycystin cation channel, PKD1/PKD2

PFAM

PF00036
PF13202
PF13405
PF00520
PF08016

PRINTS

PR00500
PR01433

PIRSF

SMART

SM00054

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt