Mus musculus Protein: Smc1b | |||||||||||||||||||||||
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Summary | |||||||||||||||||||||||
InnateDB Protein | IDBP-170292.6 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | Smc1b | ||||||||||||||||||||||
Protein Name | structural maintenance of chromosomes 1B | ||||||||||||||||||||||
Synonyms | |||||||||||||||||||||||
Species | Mus musculus | ||||||||||||||||||||||
Ensembl Protein | ENSMUSP00000023068 | ||||||||||||||||||||||
InnateDB Gene | IDBG-170290 (Smc1b) | ||||||||||||||||||||||
Protein Structure | |||||||||||||||||||||||
UniProt Annotation | |||||||||||||||||||||||
Function | Meiosis-specific component of cohesin complex. Required for the maintenance of meiotic cohesion, but not, or only to a minor extent, for its establishment. Contributes to axial element (AE) formation and the organization of chromatin loops along the AE. Plays a key role in synapsis, recombination and chromosome movements. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The meiosis-specific cohesin complex probably replaces mitosis specific cohesin complex when it dissociates from chromatin during prophase I. {ECO:0000269PubMed:11564881, ECO:0000269PubMed:15146193}. | ||||||||||||||||||||||
Subcellular Localization | Nucleus. Chromosome. Chromosome, centromere. Note=Associates with chromatin. In prophase I stage of meiosis, localizes along the AE of synaptonemal complexes. In late- pachytene-diplotene, the bulk of protein dissociates from the chromosome arms probably because of phosphorylation by PLK, except at centromeres, where cohesin complexes remain. Remains chromatin associated at the centromeres up to metaphase II. At anaphase II, dissociates from centromeres, allowing chromosomes segregation. | ||||||||||||||||||||||
Disease Associations | |||||||||||||||||||||||
Tissue Specificity | Testis and ovary specific. Not expressed in somatic cells. | ||||||||||||||||||||||
Comments | |||||||||||||||||||||||
Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||||||||||||
PDB ID | MGI:2154049 | ||||||||||||||||||||||
InterPro |
IPR003395
RecF/RecN/SMC, N-terminal IPR010935 SMCs flexible hinge IPR010978 tRNA-binding arm IPR027417 P-loop containing nucleoside triphosphate hydrolase |
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PFAM |
PF02463
PF06470 |
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PRINTS | |||||||||||||||||||||||
PIRSF | |||||||||||||||||||||||
SMART |
SM00968
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TIGRFAMs | |||||||||||||||||||||||
Post-translational Modifications | |||||||||||||||||||||||
Modification | |||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||
SwissProt | Q920F6 | ||||||||||||||||||||||
PhosphoSite | PhosphoSite-Q920F6 | ||||||||||||||||||||||
TrEMBL | A1L2Z0 | ||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | 140557 | ||||||||||||||||||||||
UniGene | Mm.182737 | ||||||||||||||||||||||
RefSeq | NP_536718 | ||||||||||||||||||||||
MGI ID | |||||||||||||||||||||||
MGI Symbol | Smc1b | ||||||||||||||||||||||
OMIM | |||||||||||||||||||||||
CCDS | CCDS27718 | ||||||||||||||||||||||
HPRD | |||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
EMBL | AF303827 BC129800 CH466550 | ||||||||||||||||||||||
GenPept | AAI29801 AAL09333 EDL04440 | ||||||||||||||||||||||