InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Vdac1

Summary

InnateDB Protein

IDBP-171109.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Vdac1

Protein Name

voltage-dependent anion channel 1

Synonyms

AL033343; Vdac5;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000099819

InnateDB Gene

IDBG-171107 (Vdac1)

Protein Structure

UniProt Annotation

Function

Forms a channel through the mitochondrial outer membrane and also the plasma membrane. The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules; in the plasma membrane it is involved in cell volume regulation and apoptosis. It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective. May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis. {ECO:0000269PubMed:10716730, ECO:0000269PubMed:15477379, ECO:0000269PubMed:18988731}.

Subcellular Localization

Isoform Mt-VDAC1: Mitochondrion outer membrane; Multi-pass membrane protein.Isoform Pl-VDAC1: Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

High levels of expression detected in heart, kidney, brain, and skeletal muscle. Not expressed in testis. {ECO:0000269PubMed:8660977}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
They are also associated with 72 interaction(s) predicted by orthology.

Experimentally validated
Total	26 [view]
Protein-Protein	26 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	72 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0005515	protein binding
GO:0008308	voltage-gated anion channel activity
GO:0015288	porin activity

Biological Process

GO:0001662	behavioral fear response
GO:0006820	anion transport
GO:0006915	apoptotic process
GO:0007268	synaptic transmission
GO:0007270	neuron-neuron synaptic transmission
GO:0007612	learning
GO:0030855	epithelial cell differentiation
GO:0044070	regulation of anion transport
GO:0055085	transmembrane transport

Cellular Component

GO:0005634	nucleus
GO:0005739	mitochondrion
GO:0005741	mitochondrial outer membrane
GO:0005743	mitochondrial inner membrane
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0042645	mitochondrial nucleoid
GO:0046930	pore complex
GO:0070062	extracellular vesicular exosome