InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tmem59

Summary

InnateDB Protein

IDBP-171318.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tmem59

Protein Name

transmembrane protein 59

Synonyms

1110001M20Rik; 3110046P06Rik; AI256529; D4Ertd20e; MTDCF1; ORF18;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000030361

InnateDB Gene

IDBG-171316 (Tmem59)

Protein Structure

UniProt Annotation

Function

Acts as a regulator of autophagy in response to S.aureus infection by promoting activation of LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C). Acts by interacting with ATG16L1, leading to promote a functional complex between LC3 and ATG16L1 and promoting LC3 lipidation and subsequent activation of autophagy. Modulates the O-glycosylation and complex N-glycosylation steps occurring during the Golgi maturation of several proteins such as APP, BACE1, SEAP or PRNP. Inhibits APP transport to the cell surface and further shedding (By similarity). {ECO:0000250}.

Subcellular Localization

Late endosome membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Lysosome membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Note=Mainly localizes to late endosomes/lysosomes. Probably first exported to the cell surface and then actively endocytosed to transiently localize in early endosomes on its way to the late endosomal/lysosomal compartment where it becomes quickly degraded (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004175	endopeptidase activity
GO:0004867	serine-type endopeptidase inhibitor activity
GO:0005515	protein binding

Biological Process

GO:0006508	proteolysis
GO:0006914	autophagy
GO:0010508	positive regulation of autophagy
GO:0010955	negative regulation of protein processing
GO:0090005	negative regulation of establishment of protein localization to plasma membrane
GO:0090285	negative regulation of protein glycosylation in Golgi

Cellular Component

GO:0000137	Golgi cis cisterna
GO:0000138	Golgi trans cisterna
GO:0000139	Golgi membrane
GO:0005764	lysosome
GO:0005765	lysosomal membrane
GO:0005770	late endosome
GO:0005797	Golgi medial cisterna
GO:0005886	plasma membrane
GO:0016021	integral component of membrane
GO:0031902	late endosome membrane
GO:0070062	extracellular vesicular exosome