Version 5.4
Homo sapiens Protein: VOPP1
Summary
InnateDB Protein IDBP-17185.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol VOPP1
Protein Name vesicular, overexpressed in cancer, prosurvival protein 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000285279
InnateDB Gene IDBG-17183 (VOPP1)
Protein Structure
UniProt Annotation
Function Increases the transcriptional activity of NFKB1 by facilitating its nuclear translocation, DNA-binding and associated apoptotic response, when overexpressed. {ECO:0000269PubMed:15735698}.
Subcellular Localization Cytoplasmic vesicle membrane {ECO:0000269PubMed:20571887}; Single-pass type I membrane protein {ECO:0000269PubMed:20571887}. Note=When overexpressed, localizes in the nucleus and perinuclear regions.
Disease Associations
Tissue Specificity Widely expressed with highest levels in thymus and ovary. {ECO:0000269PubMed:11916499}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004871 signal transducer activity
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007165 signal transduction
Cellular Component
GO:0005768 endosome
GO:0030659 cytoplasmic vesicle membrane
GO:0031301 integral component of organelle membrane
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q96AW1
PhosphoSite PhosphoSite-Q96AW1
TrEMBL C9JTY8
UniProt Splice Variant
Entrez Gene 81552
UniGene Hs.738657
RefSeq NP_110423
HUGO HGNC:34518
OMIM 611915
CCDS CCDS47588
HPRD 08526
IMGT
EMBL AB097004 AC073237 AC073347 AC099681 AF395824 AK075391 AK092992 AK314338 AK315882 AL136610 BC016650 CH236957 CH471201 CR533483
GenPept AAH16650 AAK82888 BAC11590 BAC77357 BAF98773 BAG36981 BAG52634 CAB66545 CAG38514 EAL23811 EAW50969

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca