InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Rnf5

Summary

InnateDB Protein

IDBP-172218.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rnf5

Protein Name

ring finger protein 5

Synonyms

2410131O05Rik; AA407576; NG2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000015622

InnateDB Gene

IDBG-172216 (Rnf5)

Protein Structure

UniProt Annotation

Function

Has E2-dependent E3 ubiquitin-protein ligase activity. May function together with E2 ubiquitin-conjugating enzymes UBE2D1/UBCH5A and UBE2D2/UBC4. Mediates ubiquitination of PXN/paxillin. May be involved in regulation of cell motility and localization of PXN/paxillin. Mediates the 'Lys-63'-linked polyubiquitination of JKAMP thereby regulating JKAMP function by decreasing its association with components of the proteasome and ERAD; the ubiquitination appears to involve E2 ubiquitin- conjugating enzyme UBE2N. Mediates the 'Lys-48'-linked polyubiquitination of TMEM173 at 'Lys-150 'leading to its proteasomal degradation; the ubiquitination occurrs in mitochondria after viral transfection and regulates antiviral responses (By similarity). {ECO:0000250}.

Subcellular Localization

Membrane {ECO:0000269PubMed:12861019}; Multi-pass membrane protein {ECO:0000269PubMed:12861019}. Mitochondrion membrane {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000250}. Note=Predominantly located in the plasma membrane, with some localization occurring within cytoplasmic organelles.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 28 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	28 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity
GO:0046872	metal ion binding

Biological Process

GO:0009617	response to bacterium
GO:0010507	negative regulation of autophagy
GO:0016567	protein ubiquitination
GO:0031648	protein destabilization
GO:0044257	cellular protein catabolic process
GO:0070534	protein K63-linked ubiquitination
GO:0070936	protein K48-linked ubiquitination
GO:0071712	ER-associated misfolded protein catabolic process
GO:2000785	regulation of autophagic vacuole assembly