InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Il3

Summary

InnateDB Protein

IDBP-172894.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Il3

Protein Name

interleukin 3

Synonyms

BPA; Csfmu; HCGF; Il-3; MCGF; PSF;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000019058

InnateDB Gene

IDBG-172892 (Il3)

Protein Structure

UniProt Annotation

Function

Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages.This CSF induces granulocytes, macrophages, mast cells, stem cells, erythroid cells, eosinophils and megakaryocytes.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Activated T-cells, mast cells, natural killer cells.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	1 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005125	cytokine activity
GO:0005135	interleukin-3 receptor binding
GO:0008083	growth factor activity

Biological Process

GO:0001666	response to hypoxia
GO:0001934	positive regulation of protein phosphorylation
GO:0002763	positive regulation of myeloid leukocyte differentiation
GO:0006110	regulation of glycolytic process
GO:0006954	inflammatory response
GO:0006955	immune response
GO:0008284	positive regulation of cell proliferation
GO:0010468	regulation of gene expression
GO:0010507	negative regulation of autophagy
GO:0019221	cytokine-mediated signaling pathway
GO:0033026	negative regulation of mast cell apoptotic process
GO:0033028	myeloid cell apoptotic process
GO:0035304	regulation of protein dephosphorylation
GO:0043066	negative regulation of apoptotic process
GO:0046330	positive regulation of JNK cascade
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation
GO:0070668	positive regulation of mast cell proliferation
GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand