Mus musculus Protein: Ly75
Summary
InnateDB Protein IDBP-173048.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ly75
Protein Name lymphocyte antigen 75
Synonyms CD205; DEC-205; DEC205;
Species Mus musculus
Ensembl Protein ENSMUSP00000028362
InnateDB Gene IDBG-173046 (Ly75)
Protein Structure
UniProt Annotation
Function Acts as an endocytic receptor to direct captured antigens from the extracellular space to a specialized antigen- processing compartment. Causes reduced proliferation of B lymphocytes (By similarity). {ECO:0000250}.
Subcellular Localization Membrane {ECO:0000269PubMed:7553896}; Single-pass type I membrane protein {ECO:0000269PubMed:7553896}.
Disease Associations
Tissue Specificity Expressed in dendritic and thymic epithelial cells and lymph nodes. {ECO:0000269PubMed:7553896, ECO:0000269PubMed:7753172}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0030246 carbohydrate binding
Biological Process
GO:0006897 endocytosis
Cellular Component
GO:0009897 external side of plasma membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:106662
InterPro IPR000562 Fibronectin, type II, collagen-binding
IPR000772 Ricin B lectin domain
IPR001304 C-type lectin
IPR013806 Kringle-like fold
IPR016187 C-type lectin fold
PFAM PF00040
PF00652
PF14200
PF00059
PRINTS
PIRSF
SMART SM00059
SM00458
SM00034
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q60767
PhosphoSite PhosphoSite-Q60767
TrEMBL
UniProt Splice Variant
Entrez Gene 17076
UniGene Mm.405800
RefSeq NP_038853
MGI ID
MGI Symbol Ly75
OMIM
CCDS CCDS38126
HPRD
IMGT
EMBL AF395445 AK049301 BC150734 U19271
GenPept AAA80215 AAI50735 AAK81722 BAC33668