Version 5.4
Mus musculus Protein: Ppp4r2
Summary
InnateDB Protein IDBP-173143.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ppp4r2
Protein Name protein phosphatase 4, regulatory subunit 2
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000066314
InnateDB Gene IDBG-173141 (Ppp4r2)
Protein Structure
UniProt Annotation
Function Regulatory subunit of serine/threonine-protein phosphatase 4 (PP4). May regulate the activity of PPP4C at centrosomal microtubule organizing centers. Its interaction with the SMN complex leads to enhance the temporal localization of snRNPs, suggesting a role of PPP4C in maturation of spliceosomal snRNPs. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on 'Ser-140' (gamma-H2AFX) generated during DNA replication and required for DNA double strand break repair (By similarity). Mediates RPA2 dephosphorylation by recruiting PPP4C to RPA2 in a DNA damage- dependent manner. RPA2 dephosphorylation is required for the efficient RPA2-mediated recruitment of RAD51 to chromatin following double strand breaks, an essential step for DNA repair (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Nucleus {ECO:0000250}. Note=Ionizing radiation induces relocalization to nuclear foci and colocalization with RPA2. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 20 interaction(s) predicted by orthology.
Predicted by orthology
Total 20 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0030362 protein phosphatase type 4 regulator activity
GO:0030674 protein binding, bridging
Biological Process
GO:0002244 hematopoietic progenitor cell differentiation
GO:0006397 mRNA processing
GO:0008380 RNA splicing
GO:0010569 regulation of double-strand break repair via homologous recombination
GO:0050790 regulation of catalytic activity
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005815 microtubule organizing center
GO:0030289 protein phosphatase 4 complex
Protein Structure and Domains
PDB ID MGI:3027896
InterPro IPR015267 Protein phosphatase 4 core regulatory subunit R2
PFAM PF09184
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q0VGB7
PhosphoSite PhosphoSite-Q0VGB7
TrEMBL
UniProt Splice Variant
Entrez Gene 232314
UniGene Mm.27223
RefSeq NP_891984
MGI ID
MGI Symbol Ppp4r2
OMIM
CCDS CCDS20391
HPRD
IMGT
EMBL AK082539 BC056340 BC062117 BC098464 BC110429
GenPept AAH56340 AAH62117 AAH98464 AAI10430 BAC38523

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca