InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Apc2

Summary

InnateDB Protein

IDBP-173539.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Apc2

Protein Name

adenomatosis polyposis coli 2

Synonyms

AI852447; APCL; R75424;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000020349

InnateDB Gene

IDBG-173537 (Apc2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 20 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	0
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	20 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005488	binding
GO:0005515	protein binding
GO:0008013	beta-catenin binding
GO:0008017	microtubule binding

Biological Process

GO:0016055	Wnt signaling pathway
GO:0035414	negative regulation of catenin import into nucleus
GO:0090090	negative regulation of canonical Wnt signaling pathway

Cellular Component

GO:0005794	Golgi apparatus
GO:0005881	cytoplasmic microtubule
GO:0005884	actin filament
GO:0016342	catenin complex
GO:0031258	lamellipodium membrane
GO:0048471	perinuclear region of cytoplasm

Protein Structure and Domains

PDB ID

MGI:1346052

InterPro

IPR000225 Armadillo
IPR009053 Prefoldin
IPR009223 Adenomatous polyposis coli protein, cysteine-rich repeat
IPR009224 SAMP
IPR009234 Adenomatous polyposis coli protein basic domain
IPR016024 Armadillo-type fold
IPR026831 Adenomatous polyposis coli domain

PFAM

PF00514
PF05923
PF05924
PF05956
PF11414

PRINTS

PIRSF

SMART

SM00185

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite