InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Hmbox1

Summary

InnateDB Protein

IDBP-173768.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hmbox1

Protein Name

homeobox containing 1

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000066905

InnateDB Gene

IDBG-173764 (Hmbox1)

Protein Structure

UniProt Annotation

Function

Transcription factor. Acts as a transcriptional repressor (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00108}. Cytoplasm {ECO:0000250}. Note=Predominantly detected in cytoplasm. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

MGI:2445066

InterPro

IPR001356 Homeobox domain
IPR006899 Hepatocyte nuclear factor 1, N-terminal
IPR009057 Homeodomain-like
IPR010982 Lambda repressor-like, DNA-binding domain

PFAM

PF00046
PF04814
PF13413

PRINTS

PIRSF

SMART

SM00389

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8BJA3