InnateDB Protein
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IDBP-173870.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Larp6
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Protein Name
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La ribonucleoprotein domain family, member 6
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Synonyms
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5430431G03Rik; Achn; AI552438;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000040309
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InnateDB Gene
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IDBG-173868 (Larp6)
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Protein Structure
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Function |
Regulates the coordinated translation of type I collagen alpha-1 and alpha-2 mRNAs, CO1A1 and CO1A2. Stabilizes mRNAs through high-affinity binding of a stem-loop structure in their 5' UTR. This regulation requires VIM and MYH10 filaments, and the helicase DHX9 (By similarity). {ECO:0000250}.
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Subcellular Localization |
Cytoplasm. Nucleus. Note=Shuttles between the nucleus and the cytoplasm. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Expressed in numerous tissues. Highest expression in heart and brain, intermediate in kidney, skeletal muscle and testis, lowest expression in testis (at protein level). {ECO:0000269PubMed:17383118}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
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Predicted by orthology |
Total |
2 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1914807
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InterPro |
IPR002344
Lupus La protein
IPR006630
RNA-binding protein Lupus La
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PFAM |
PF05383
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PRINTS |
PR00302
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PIRSF |
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SMART |
SM00715
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TIGRFAMs |
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Modification |
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SwissProt |
Q8BN59
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PhosphoSite |
PhosphoSite-Q8BN59
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TrEMBL |
Q8CBL4
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UniProt Splice Variant |
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Entrez Gene |
67557
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UniGene |
Mm.44546
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RefSeq |
NP_080511
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MGI ID |
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MGI Symbol |
Larp6
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OMIM |
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CCDS |
CCDS23258
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HPRD |
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IMGT |
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EMBL |
AK017372
AK020966
AK035809
AK039614
AK042616
AK087521
BC090615
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GenPept |
AAH90615
BAB30713
BAB32263
BAC29193
BAC30400
BAC31306
BAC39909
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