Version 5.4
| Homo sapiens Protein: KLHL22 | |||||||||||||||||||
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| Summary | |||||||||||||||||||
| InnateDB Protein | IDBP-1753.5 | ||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
| Gene Symbol | KLHL22 | ||||||||||||||||||
| Protein Name | kelch-like 22 (Drosophila) | ||||||||||||||||||
| Synonyms | |||||||||||||||||||
| Species | Homo sapiens | ||||||||||||||||||
| Ensembl Protein | ENSP00000331682 | ||||||||||||||||||
| InnateDB Gene | IDBG-1734 (KLHL22) | ||||||||||||||||||
| Protein Structure |
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| UniProt Annotation | |||||||||||||||||||
| Function | Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for chromosome alignment and localization of PLK1 at kinetochores. The BCR(KLHL22) ubiquitin ligase complex mediates monoubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation. Monoubiquitination of PLK1 does not lead to PLK1 degradation. {ECO:0000269PubMed:19995937, ECO:0000269PubMed:23455478}. | ||||||||||||||||||
| Subcellular Localization | Cytoplasm {ECO:0000269PubMed:23455478}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269PubMed:23455478}. Cytoplasm, cytoskeleton, spindle {ECO:0000269PubMed:23455478}. Note=Mainly. cytoplasmic in prophase and prometaphase. Associates with the mitotic spindle as the cells reach chromosome bi-orientation. Localizes to the centrosomes shortly before cells enter anaphase After anaphase onset, predominantly associates with the polar microtubules connecting the 2 opposing centrosomes and gradually diffuses into the cytoplasm during telophase. | ||||||||||||||||||
| Disease Associations | |||||||||||||||||||
| Tissue Specificity | |||||||||||||||||||
| Comments | |||||||||||||||||||
| Interactions | |||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Protein Structure and Domains | |||||||||||||||||||
| PDB ID | |||||||||||||||||||
| InterPro |
IPR000210
BTB/POZ-like IPR006652 Kelch repeat type 1 IPR011333 BTB/POZ fold IPR011498 Kelch repeat type 2 IPR011705 BTB/Kelch-associated IPR013069 BTB/POZ IPR017096 Kelch-like protein, gigaxonin type |
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| PFAM |
PF01344
PF07646 PF07707 PF00651 |
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| PRINTS | |||||||||||||||||||
| PIRSF |
PIRSF037037
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| SMART |
SM00225
SM00612 SM00875 |
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| TIGRFAMs | |||||||||||||||||||
| Post-translational Modifications | |||||||||||||||||||
| Modification | |||||||||||||||||||
| Cross-References | |||||||||||||||||||
| SwissProt | Q53GT1 | ||||||||||||||||||
| PhosphoSite | PhosphoSite-Q53GT1 | ||||||||||||||||||
| TrEMBL | C9J2T1 | ||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||
| Entrez Gene | 84861 | ||||||||||||||||||
| UniGene | |||||||||||||||||||
| RefSeq | NP_116164 | ||||||||||||||||||
| HUGO | HGNC:25888 | ||||||||||||||||||
| OMIM | |||||||||||||||||||
| CCDS | CCDS13780 | ||||||||||||||||||
| HPRD | 07858 | ||||||||||||||||||
| IMGT | |||||||||||||||||||
| EMBL | AC007731 AK027266 AK222850 AK290669 AK294682 BC015923 CH471176 CR456352 | ||||||||||||||||||
| GenPept | AAH15923 BAB55007 BAD96570 BAF83358 BAH11847 CAG30238 EAX02961 EAX02962 EAX02963 | ||||||||||||||||||