Version 5.4
Homo sapiens Protein: FRYL
Summary
InnateDB Protein IDBP-17563.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FRYL
Protein Name FRY-like
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000351113
InnateDB Gene IDBG-17559 (FRYL)
Protein Structure
UniProt Annotation
Function Plays a key role in maintaining the integrity of polarized cell extensions during morphogenesis, regulates the actin cytoskeleton and plays a key role in patterning sensory neuron dendritic fields by promoting avoidance between homologous dendrites as well as by limiting dendritic branching (By similarity). May function as a transcriptional activator. {ECO:0000250, ECO:0000269PubMed:16061630}.
Subcellular Localization
Disease Associations Note=A chromosomal aberration involving FRYL is found in treatment-related acute lymphoblastic leukemia (ALL). Translocation t(4;11)(p12;q23) that forms a KMT2A/MLL1-FRYL fusion protein.
Tissue Specificity Widely expressed with higher expression in colon, placenta, brain and cells of lymphoid origin. {ECO:0000269PubMed:16061630}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
Experimentally validated
Total 14 [view]
Protein-Protein 14 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005488 binding
GO:0005515 protein binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
Cellular Component
Protein Structure and Domains
PDB ID
InterPro IPR016024 Armadillo-type fold
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O94915
PhosphoSite PhosphoSite-O94915
TrEMBL
UniProt Splice Variant
Entrez Gene 285527
UniGene Hs.595553
RefSeq NP_055845
HUGO HGNC:29127
OMIM
CCDS CCDS43227
HPRD
IMGT
EMBL AB020633 AC068037 AC096952 AL137546 BC021803 U80082
GenPept AAD00351 AAH21803 BAA74849 CAB70804

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca