InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: KLRG1

Summary

InnateDB Protein

IDBP-17568.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KLRG1

Protein Name

killer cell lectin-like receptor subfamily G, member 1

Synonyms

2F1; CLEC15A; MAFA; MAFA-2F1; MAFA-L; MAFA-LIKE;

Species

Homo sapiens

Ensembl Protein

ENSP00000349477

InnateDB Gene

IDBG-17564 (KLRG1)

Protein Structure

UniProt Annotation

Function

Plays an inhibitory role on natural killer (NK) cells and T-cell functions upon binding to their non-MHC ligands. May mediate missing self recognition by binding to a highly conserved site on classical cadherins, enabling it to monitor expression of E-cadherin/CDH1, N-cadherin/CDH2 and R-cadherin/CDH4 on target cells. {ECO:0000269PubMed:19604491}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:19604491}; Single-pass type II membrane protein {ECO:0000269PubMed:19604491}.

Disease Associations

Tissue Specificity

Expressed specifically on natural killer (NK) cells and T-cells, mainly CD8 T-cells. {ECO:0000269PubMed:15879103, ECO:0000269PubMed:9842918}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004872	receptor activity
GO:0030246	carbohydrate binding

Biological Process

GO:0006954	inflammatory response
GO:0006968	cellular defense response
GO:0007166	cell surface receptor signaling pathway
GO:0045087	innate immune response
GO:0050776	regulation of immune response