InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Smad6

Summary

InnateDB Protein

IDBP-175759.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Smad6

Protein Name

MAD homolog 6 (Drosophila)

Synonyms

b2b390Clo; Madh6;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000036285

InnateDB Gene

IDBG-175757 (Smad6)

Protein Structure

UniProt Annotation

Function

Binds to regulatory elements in target promoter regions (By similarity). May block the BMP-SMAD1 signaling pathway by competing with SMAD4 for receptor-activated SMAD1-binding (By similarity). Acts as a mediator of TGF-beta and BMP antiflammatory activity. Suppresses IL1R-TLR signaling through its direct interaction with PEL1, preventing NF-kappa-B activation, nuclear transport and NF-kappa-B-mediated expression of proinflammatory genes. {ECO:0000250, ECO:0000269PubMed:16951688}.

Subcellular Localization

Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Ubiquitous in various organs, with higher levels in lung.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
They are also associated with 38 interaction(s) predicted by orthology.

Experimentally validated
Total	22 [view]
Protein-Protein	22 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	38 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003682	chromatin binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0030617	transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity
GO:0031625	ubiquitin protein ligase binding
GO:0034713	type I transforming growth factor beta receptor binding
GO:0044212	transcription regulatory region DNA binding
GO:0046872	metal ion binding
GO:0070410	co-SMAD binding
GO:0070411	I-SMAD binding
GO:0070412	R-SMAD binding
GO:0070698	type I activin receptor binding

Biological Process

GO:0001657	ureteric bud development
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006955	immune response
GO:0007179	transforming growth factor beta receptor signaling pathway
GO:0007352	zygotic specification of dorsal/ventral axis
GO:0008285	negative regulation of cell proliferation
GO:0010991	negative regulation of SMAD protein complex assembly
GO:0030509	BMP signaling pathway
GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway
GO:0030514	negative regulation of BMP signaling pathway
GO:0031589	cell-substrate adhesion
GO:0034616	response to laminar fluid shear stress
GO:0035556	intracellular signal transduction
GO:0043066	negative regulation of apoptotic process
GO:0043627	response to estrogen
GO:0045444	fat cell differentiation
GO:0045907	positive regulation of vasoconstriction
GO:0045908	negative regulation of vasodilation
GO:0060394	negative regulation of pathway-restricted SMAD protein phosphorylation
GO:0060948	cardiac vascular smooth muscle cell development
GO:0060977	coronary vasculature morphogenesis