InnateDB Protein
|
IDBP-175762.6
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
Bnip3l
|
Protein Name
|
BCL2/adenovirus E1B interacting protein 3-like
|
Synonyms
|
C86132; D14Ertd719e; Nip3L; Nix;
|
Species
|
Mus musculus
|
Ensembl Protein
|
ENSMUSP00000022634
|
InnateDB Gene
|
IDBG-175760 (Bnip3l)
|
Protein Structure
|
|
Function |
Induces apoptosis. Interacts with viral and cellular anti-apoptosis proteins. Can overcome the suppressors BCL-2 and BCL-XL, although high levels of BCL-XL expression will inhibit apoptosis. Inhibits apoptosis induced by BNIP3. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates to mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix (By similarity). May function as a tumor suppressor (By similarity). {ECO:0000250}.
|
Subcellular Localization |
Nucleus envelope {ECO:0000250}. Endoplasmic reticulum {ECO:0000250}. Mitochondrion outer membrane {ECO:0000250}. Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Note=Colocalizes with SPATA18 at the mitochondrion outer membrane. {ECO:0000250}.
|
Disease Associations |
|
Tissue Specificity |
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 29 interaction(s) predicted by orthology.
Experimentally validated |
Total |
11
[view]
|
Protein-Protein |
11
[view]
|
Protein-DNA |
0
|
Protein-RNA |
0
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
Predicted by orthology |
Total |
29 [view]
|
|
|
Molecular Function |
|
Biological Process |
|
Cellular Component |
|
PDB ID |
MGI:1332659
|
InterPro |
IPR010548
BNIP3
|
PFAM |
PF06553
|
PRINTS |
|
PIRSF |
|
SMART |
|
TIGRFAMs |
|
Modification |
|
SwissProt |
Q9Z2F7
|
PhosphoSite |
PhosphoSite-Q9Z2F7
|
TrEMBL |
|
UniProt Splice Variant |
|
Entrez Gene |
12177
|
UniGene |
Mm.427119
|
RefSeq |
NP_033891
|
MGI ID |
|
MGI Symbol |
Bnip3l
|
OMIM |
|
CCDS |
CCDS27227
|
HPRD |
|
IMGT |
|
EMBL |
AF067395
AK004667
AK007920
AK013467
AK018668
AK139950
AK155040
BC085237
|
GenPept |
AAD03588
AAH85237
BAB23456
BAB25351
BAB28869
BAB31334
BAE24194
BAE33007
|
|
|