InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RICTOR

Summary

InnateDB Protein

IDBP-17690.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RICTOR

Protein Name

RPTOR independent companion of MTOR, complex 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000349959

InnateDB Gene

IDBG-17688 (RICTOR)

Protein Structure

UniProt Annotation

Function

Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient- insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. Plays an essential role in embryonic growth and development. {ECO:0000269PubMed:15268862, ECO:0000269PubMed:15467718, ECO:0000269PubMed:15718470}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 112 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	112 [view]
Protein-Protein	110 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	2 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005488	binding
GO:0005515	protein binding

Biological Process

GO:0007173	epidermal growth factor receptor signaling pathway
GO:0008543	fibroblast growth factor receptor signaling pathway
GO:0009790	embryo development
GO:0031295	T cell costimulation
GO:0031532	actin cytoskeleton reorganization
GO:0031929	TOR signaling
GO:0032008	positive regulation of TOR signaling
GO:0032956	regulation of actin cytoskeleton organization
GO:0038095	Fc-epsilon receptor signaling pathway
GO:0045087	innate immune response (InnateDB)
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0048015	phosphatidylinositol-mediated signaling
GO:0051896	regulation of protein kinase B signaling